Endocrine Abstracts

WNK1 (With-No-K, lysine) and WNK4 are serine/threonine kinases, mutated in Gordon syndrome (Pseudohypoaldosteronism Type II), a dominant, hypertensive, hyperkalaemic disorder; implicating this novel WNK pathway in normal regulation of blood pressure (BP) and electrolyte balance. Previous Xenopus oocyte work implicates WNK4 in regulation of K+ secretion via ROMK (renal outer medullary K+ channel) and Cl- transport pathways both paracellularly via tight junctions (claudin...

Introduction: Psoriasis is a systemic inflammatory skin disease, which is associated with increased cardiovascular disease (CVD) potentially through metabolic derangements due to chronic inflammation. Serum adiponectin appears to decrease the risk of CVD and has been shown to negatively associate with waist size and insulin resistance (IR), both of which are increased in psoriasis. It is unknown, however, if psoriasis is associated with decreased adiponectin levels beyond trad...